2. Signaling Pathways
  3. Epigenetics
  4. Epigenetic Reader Domain
  5. Epigenetic Reader Domain Control

Epigenetic Reader Domain Control

Epigenetic Reader Domain Controls (9):

Cat. No. Product Name Effect Purity
  • HY-107443A
    (R)-I-BET762 carboxylic acid
    		Control 99.50%
    (R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1.
  • HY-119254A
    trans-BAY-850
    		Control 98.12%
    trans-BAY-850 is the trans isomer of BAY-850 (HY-119254). BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
  • HY-13032A
    GSK 525768A
    		Control 99.62%
    GSK 525768A is the inactive enantiomer of GSK525762A. GSK 525768A has no activity towards BET.
  • HY-157592
    MMH2-NR
    		Control 98.72%
    MMH2-NR a negtive control of MMH2. MMH2 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader.
  • HY-101125B
    D-Moses
    		Control
    D-Moses (D-45) is an enantiomer of L-Moses (HY-101125). L-Moses (L-45) is a potent and selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor. D-Moses shows no observable binding for PCAF Brd. D-Moses can be used as an inactive control compound to L-Moses.
  • HY-157591
    MMH1-NR
    		Control 99.36%
    MMH1-NR, containing a non-reactive (ethyl) group is a negative control of MMH1. MMH1 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader.
  • HY-169980
    Mivebresib-alkyne
    		Control
    Mivebresib-alkyne (Compound 25), a Mivebresib (HY-100015) derivative, can be used for BRD4 targeted PROTAC synthesis through click reaction.
  • HY-112504D
    (R)-INCB054329
    		Control
    (R)-INCB054329 is the isomer of INCB054329 (HY-112504), and can be used as an experimental control. INCB054329 is a potent BET inhibitor.
  • HY-138563A
    (2R,3R)-GSK973
    		Control
    (2R,3R)-GSK973 is an isomer of GSK973. GSK973 is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family.